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KMID : 0352720010250030107
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Journal of Ginseng Research
2001 Volume.25 No. 3 p.107 ~ p.111
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Cancer Chemopreventive Compounds of Red Ginseng Produced from panax ginseng C.A. Meyer
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Taik Koo Yun/Taik Koo Yun
Yun Sil Lee/You Hui Lee/Hyo Yung Yun
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Abstract
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Fresh Panax gineng C.A. cultivated in Korea(Korean red ginseng) was found to be ineffective as anticarcinogenic or cancer preventive in experimental animal model or in human case-control and cohort study. However, when treated with heat, the fresh ginseng, white ginseng were highly effective cancer preventives. Four compounds including 20(S)-ginsenoside Rh
1
(Rh
1
), 20(S)-ginsenoside Rh
2
(Rh
2
), 20(S)0-siwenoside Rg
3
(Rg
3
) and sinsenoside Rg
\sub
5/ were consequently purified from Korean red ginseng, and they were tested by Yun\`s 9 week medium-term anticarcinogenicity test model. Rg
3
and Rg
\sub
5/ statistically significantlydecreased the incidence of benzo(a)pyrene-induced mouse lung tumor, Rh
2
showed tendency of decrease, and Rh1 showed no effect. It is, therefore, concluded that Rg
3
and Rg
\sub
5/ are active anticarcinogenic components in res ginseng and they either singularly or synergistically act in the prevention of cancer.
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KEYWORD
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Cancer chemoprevention, benzo(a)pyrene, lung tumor, Panax ginseng, Korean ginseng, gisenoside Rg
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